Travel from Rome to Marsala and discover this Sicilia city of 78.000 inhabitants. The distance from Rome to Marsala is 721 kilometers; with Wanderio you can compare the available trains, buses, and flights to get from Rome to Marsala, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a flight from Rome to Marsala, you’ll get to your destination in about 1 hour on average; flight ticket prices start from 46 €. Going from Rome to Marsala by bus instead? Prices for your ticket start from 40 € and the bus journey takes about 14 hours on average.